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Department of Chemistry, Physics, and Atmospheric Sciences – CHEMISTRY
College of Science, Engineering, and Technology

 

Chemistry is the study of how matter behaves at its most basic level. The central science, chemistry, is involved in everything that we do. Its applications stretch across all areas of life, including medicine, engineering and agriculture.

Ashton T. Hamme II

Professor & Interim Chair
 hamme2

Physical location:

John A. Peoples Science Building
Office: room #539

Contact:
E-mail: ashton.t.hamme@jsums.edu
Tel: (601) 979-2171
Fax: (601) 979-3674

Hamme Research Group

Teaching
Organic Chemistry Part I CHEM 241
Organic Chemistry Part II CHEM 242
Organic Chemistry Laboratory Part I CHML 241
Organic Chemistry Laboratory Part II CHML 242
Advanced Organic Synthesis CHEM 738


Research Interests:

The Hamme research group is interested in the synthesis of biologically active heterocyclic containing natural products and their synthetic analogues.  Our synthetic approach usually incorporates a 1,3-dipolar cycloaddition reaction of a 1,3-dipole with a functionalized alkene or alkyne to afford the corresponding heterocyclic compound which usually serves as a precursor to a more complex ring system.  Our research group is also interested in the use of pure water as a reaction medium for organic synthesis.    


Selected publications (Click here for full list)
  1. S Dadiboyena, AT Hamme, One pot spiropyrazoline synthesis via intramolecular cyclization/methylation, Tetrahedron letters 52 (20), 2536-2539, 2011.
  2. Dadiboyena, S.; Valente, E. J.; Hamme, A. T. II “Synthesis of Novel Pyrazoles via [2+3]-Dipolar Cycloaddition Using Alkyne Surrogates” Tetrahedron Lett. 2010, 51, 1341-1343.
  3. Ellis, E. D.; Xu, J.; Valente, E. J.; Hamme, A. T. II “Construction of Novel Spiroisoxazolines via Intramolecular Cyclization/Methylation” Tetrahedron Lett. 2009, 50, 5516-5519.
  4. McClendon, E.; Omollo, A. O.; Valente, E. J.; Hamme, A. T. II “Oxonium Ion Mediated Synthesis of 4-Substituted Spiro-Isoxazolines” Tetrahedron Lett. 2009, 50, 533-535.
  5. Dadiboyena, S.; Valente, E. J.; Hamme, A. T. II “A Novel Synthesis of 1,3,5-Trisubstituted Pyrazoles through a Spiro-pyrazoline Intermediate via a Tandem 1,3-Dipolar Cycloaddition/Elimination” Tetrahedron Lett. 2009, 50, 291-294.
  6. Xu, J.; Hamme, A. T. II “Efficient Access to Isoxazoles from Alkenes” Synlett 2008, 919-923.
  7. Rasulev, B. F.; Toropov, A. A.; Hamme, A. T. II; Leszczynski, Jerzy.  “Multiple linear regression analysis and optimal descriptors: predicting the Cholesteryl Ester Transfer Protein inhibition activity” QSAR & Combinatorial Science 2008, 27, 595-606.
  8. Dadiboyena, S.; Xu, J.; Hamme, A. T. II “Isoxazoles from 1,1-Disubstituted Bromoalkenes” Tetrahedron Lett. 2007, 48, 1295-1298.
  9. Xu, J.; Wang, J.; Ellis, E. D.; Hamme, A. T. II “Spiroisoxazoline Synthesis via Intramolecular Cyclization/Methylation” Synthesis 2006, 3815-3818.
  10. Song, Y.; Xu, J.; Hamme, A.; Liu, Y-M. “Capillary Liquid Chromatography-Tandem Mass Spectrometry of Tetrahydroisoquinoline Derived Neurotoxins:  Study on the Blood-Brain Barrier of Rat Brain” J. Chromatogr. A 2006, 1103, 229.

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DEPARTMENT OF CHEMISTRY, PHYSICS, AND ATMOSPHERIC SCIENCES

Address

Jackson State University
Department of Chemistry
1325 J. R. Lynch St.
P.O. Box 17910
Jackson, MS 39217-0510

Contact

(601) 979-7021